{"id":2204,"date":"2023-01-16T22:48:37","date_gmt":"2023-01-16T22:48:37","guid":{"rendered":"https:\/\/www.adamsranchacds.com\/?page_id=2204"},"modified":"2024-08-10T22:11:34","modified_gmt":"2024-08-10T22:11:34","slug":"multidrug-resistance-1-mdr1-gene-mutation-3","status":"publish","type":"page","link":"https:\/\/www.adamsranchacds.com\/index.php\/health-testing\/multidrug-resistance-1-mdr1-gene-mutation-3\/","title":{"rendered":"Multidrug resistance 1 (MDR1 gene mutation)"},"content":{"rendered":"

What is the MDR1 gene?<\/strong><\/span><\/h3>\n

Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. This gene specifically codes for P-glycoprotein, which is responsible for transporting certain drugs out of the brain. If this gene is mutated, it will create a defective protein, and consequently, drugs will remain and build up in the brain to toxic levels.<\/h3>\n

This dominant gene is inherited from the parents, whether the parent has two copies of the gene or only one copy. If neither parent has a copy of the mutated MDR1 gene, then nor will the offspring.<\/h3>\n

What is the test for MDR1?<\/strong><\/h3>\n

DNA testing is now available for the MDR1 gene with either a cheek swab or a blood sample. This can be completed either at home by ordering a kit from the lab’s website, or through your veterinarian.<\/h3>\n

Once you send in the sample to the lab, you will receive the results back.<\/h3>\n

What results are possible?<\/strong><\/h3>\n

\u00a0Clear<\/strong> – both genes are Normal – If your dog is Normal\/Normal, then you don\u2019t have to worry about any drugs related to the MDR1 gene.<\/h3>\n

Carrier<\/strong> – One normal gene and one mutant gene – Dogs with even one copy of the MDR1 gene should be considered sensitive to the drugs indicated in this article.<\/h3>\n

Affected \/ At Risk<\/strong> -both genes are mutant. Listed below are drugs that should be avoided.\u00a0 They may possibly cause seizures if given to a dog that has two copies of the MDR1 mutated gene.<\/h3>\n

What drugs are not safe?<\/strong><\/h3>\n

There are multiple drugs that will affect dogs with the mutated MDR1 gene. As long as your veterinarian is aware of your dog\u2019s MDR1 status, they are able to consider which drugs are best suited for the current treatment. Those with a Normal\/Mutant gene may be less susceptible to these drugs, though they would likely react to increased doses. Below is a list of drugs that should be generally avoided in dogs with an MDR1 status, or herding breeds or mixed breeds of unknown MDR1 status.<\/h3>\n